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Amendment 3 to Article XIV of the Missouri Constitution passed into law in 2022. The amendment legalizes recreational cannabis in the state of Missouri and expands the existing medical marijuana program. While the federal government still considers cannabis a schedule I controlled substance, Missouri is the 21st state to legalize recreational use.

The amendment passed statewide in November with 53.1% of the vote. Dent County did not follow the statewide trend, with 65.9% voting against it.